Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated

corbettresearch
10 Sep

Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated

By Nicolas Antibodies , Enzymes , Exosomes , Gels , PCR , Western Blot , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , No Comments

Cell Cycle Checkpoints Cooperate to Suppress DNA– and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses

  • The DNA-dependent pattern recognition receptor, cGAS (cyclic GMP-AMP synthase), mediates communication between the DNA damage and the immune responses. Mitotic chromosome missegregation stimulates cGAS activity; however, it is unclear whether progression through mitosis is required for cancercell-intrinsic activation of anti-tumor immune responses.
  • Moreover, it is unknown whether cell cycle checkpoint disruption can restore responses in cancer cells that are recalcitrant to DNAdamage-induced inflammation. Here, we demonstrate that prolonged cell cycle arrest at the G2-mitosis boundary from either excessive DNA damage or CDK1 inhibition prevents inflammatory-stimulated gene expression and immune-mediated destruction of distal tumors. Remarkably, DNAdamage-induced inflammatory signaling is restored in a RIG-I-dependent manner upon concomitant disruption of p53 and the G2 checkpoint.
  • These findings link aberrant cell progression and p53 loss to an expanded spectrum of damage-associated molecular pattern recognition and have implications for the design of rational approaches to augment anti-tumor immune responses.
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Description: Excepted Quantities

OxiSelect Oxidative DNA Damage Quantitation Kit (AP Sites), Trial Size
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Description: DNA damage can manifest in the formation of apurinic or apyrimidinic (AP or abasic) sites. Such spontaneous base loss in mammalian cells has been estimated at between 50,000 and 200,000 sites per day. Unrepaired abasic sites can inhibit transcription and may be mutagenic. Our OxiSelect Oxidative DNA Damage Quantitation Kit provides a simple, user-friendly method for the quantitaiton DNA damage in the form of abasic sites. The assay uses an Aldehyde Reactive Probe (ARP) to specifically react with an aldehyde group on the open ring of the AP site. This allows the AP site to be labeled with Biotin, followed by detection with Streptavidin-Enzyme conjugate.

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Description: Excepted Quantities

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Monoclonal antibody for DNA/RNA Damage
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Oxidative Stress Responsive 1 (OXSR1) Antibody
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Oxidative Stress Responsive 1 (OXSR1) Antibody
abx325277-50g 50 µg
EUR 187.5

Human DNA Oxidative Demethylase ALKBH2 (ALKBH2) Protein
abx073206-20kDa1g 20 kDa; 1 g
EUR 225

Human DNA Oxidative Demethylase ALKBH2 (ALKBH2) Protein
abx073206-20kDa5g 20 kDa; 5 g
EUR 3550

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Oxidative-Stress Responsive 1 (OXSR1) Antibody
20-abx114290
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Recombinant Human DNA oxidative demethylase ALKBH2 (ALKBH2)
CSB-EP761219HU 4107 mg Ask for price

Recombinant Human DNA oxidative demethylase ALKBH2 (ALKBH2)
CSB-EP761219HU-20ug 20ug Ask for price
Description: 1-261aa

Oxidative Stress Antibodies Set | 5 antibodies
AS19-4294 each
EUR 1472

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503-100 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503-500 500ug
EUR 460

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
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EUR 518.75

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EUR 627.6

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EUR 250

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
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EUR 612.5

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Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
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EUR 787.5

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abx236027-100g 100 µg
EUR 350

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abx236027-100ug 100 ug
EUR 610.8

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
abx128290-100l 100 µl
EUR 275

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
20-abx128290
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  • 10 ug
  • 50 ug
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  • 1 mg

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
abx128290-1ml 1 ml
EUR 750

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
abx128290-200l 200 µl
EUR 337.5

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
abx146030-100ug 100 ug
EUR 469.2

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
abx146030-1096tests 10 × 96 tests Ask for price

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
abx146030-596tests 5 × 96 tests Ask for price

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody
abx146030-96tests 96 tests
EUR 337.5

Human Oxidative Stress-Responsive 1 Protein (OXSR1) Antibody
33219-05111 150 ug
EUR 215

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody
abx122927-100l 100 µl Ask for price

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody
abx122927-100ug 100 ug
EUR 469.2

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody
abx122927-20l 20 µl
EUR 337.5

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody
abx122927-50l 50 µl Ask for price

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody
abx302885-100g 100 µg
EUR 362.5

A G-quadruplex-forming RNA aptamer binds to the MTG8 TAFH domain and dissociates the leukemic AML1-MTG8 fusion protein from DNA

MTG8 (RUNX1T1) is a fusion partner of AML1 (RUNX1) in the leukemic chromosome translocation t(8;21). The AML1-MTG8 fusion gene encodes a chimeric transcription factor. One of the highly conserved domains of MTG8 is TAFH which possesses homology with human TAF4 [TATA-box binding protein (TBP)-associated factor].
To obtain specific inhibitors of the AML1-MTG8 fusion protein, we isolated RNA aptamers against the MTG8 TAFH domain using Systematic Evolution of Ligands by EXponential enrichment (SELEX). All TAF aptamers contained guanine-rich sequences. Analyses of a TAF aptamer by NMR, CD and mutagenesis revealed that it forms a parallel G-quadruplex structure in the presence of K+ .
Furthermore, the aptamer could bind to the AML1-MTG8 fusion protein and dissociate the AML1-MTG8/DNA complex, suggesting that it can inhibit the dominant negative effects of AML1-MTG8 against normal AML1 function and serve as a potential therapeutic agent for leukemia.

DNA–RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing

Heteroduplex oligonucleotides (HDOs) were a novel type of nucleic acid drugs based on an antisense oligonucleotide (ASO) strand and its complementary RNA (cRNA ) strand.
HDOs were originally designed to improve the properties of RNase H-dependent ASOs and we reported in our first paper that HDOs conjugated with an α-tocopherol ligand (Toc-HDO ) based on a gapmer ASO showed 20 times higher silencing effect to liver apolipoprotein B (apoB) mRNA in vivo than the parent ASO.
Thereafter the HDO strategy was found to be also effective for improving the properties of ASOs modulating blood-brain barrier function and ASO antimiRs which are RNase H-independent ASOs. Therefore, the HDO strategy has been shown to be versatile technology platform to develop effective nucleic acid drugs.

Site-selective RNA Functionalization via DNA-induced Structure

Methods for RNA functionalization at specific sites are in high demand, but remain a challenge, particularly for RNAs produced by transcription rather than by total synthesis. Recent studies have described acylimidazole reagents that react in high yields at 2′-OH groups stochastically at non-base-paired regions, covering much of the RNA in scattered acyl esters.
Localized reactions, if possible, could prove useful in many applications, providing functional handles at specific sites and sequences of the biopolymer. Here we describe a DNA-directed strategy for in vitro functionalization of RNA at site-localized 2′-OH groups. The method, RNA Acylation at Induced Loops (RAIL), utilizes complementary helper DNA oligonucleotides that expose gaps or loops at selected positions while protecting the remainder in DNA-RNA duplexes.
Reaction with an acylimidazole reagent is then carried out, providing high yields of 2′-OH conjugation at predetermined sites. Experiments reveal optimal helper oligodeoxynucleotide designs and conditions for the reaction, and tests of the approach are carried out to control localized ribozyme activities and to label RNAs with dual-color fluorescent dyes. The RAIL approach offers a simple and novel strategy for site-specific labeling and control of RNAs, potentially of any length and origin.

Optimization of a Method for the Simultaneous Extraction of Polar and Non-Polar Oxylipin Metabolites, DNA, RNA, Small RNA, and Protein from a Single Small Tissue Sample

A more comprehensive picture of tissue biology can be obtained through the application and integration of multiple omic technologies. However, the common challenge in working with a precious sample is having a sample too small to separately extract analytes of interest for each experiment. Considering the high heterogeneity that can be present in a single tissue sample, extracting all biomolecules from a single and undivided tissue is preferable because it allows direct comparison of results.
Here, we combined a modified Folch extraction method with DNA, RNA, small RNA, and protein extraction using two commercial kits, which allowed us to extract polar metabolites and non-polar oxylipin metabolites, DNA, RNA, small RNA, and protein simultaneously from a small tissue sample. The method was validated in terms of quantity and quality of analytes for downstream analyses.

DNA / RNA Damage Antibody
abx440040-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx440321-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx440602-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx440883-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx441164-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx441445-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx441726-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx442007-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx442288-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx443130-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx443410-100ug 100 ug
EUR 644.4

DNA / RNA Damage Antibody
abx443691-100ug 100 ug
EUR 678

DNA / RNA Damage Antibody
abx442569-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx442850-100ug 100 ug
EUR 661.2

DNA/RNA Damage Antibody
MBS8001907-0025mg 0.025mg
EUR 265

DNA/RNA Damage Antibody
MBS8001907-5x0025mg 5x0.025mg
EUR 925

DNA/RNA Damage Antibody
MBS801590-01mg 0.1mg
EUR 415

DNA/RNA Damage Antibody
MBS801590-5x01mg 5x0.1mg
EUR 1595

DNA/RNA Damage Antibody
SMC-155D 0.1mg
EUR 214.2
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody
SMC-155S 0.012mg Ask for price
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (PE)
abx444253-100g 100 µg
EUR 575

DNA / RNA Damage Antibody (HRP)
abx443410-100g 100 µg
EUR 562.5

DNA / RNA Damage Antibody (APC)
abx442569-100l 100 µl
EUR 575

DNA/RNA Damage Antibody: HRP
MBS801864-01mg 0.1mg
EUR 450

DNA/RNA Damage Antibody: HRP
MBS801864-5x01mg 5x0.1mg
EUR 1770

DNA/RNA Damage Antibody: RPE
MBS803622-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: RPE
MBS803622-5x01mg 5x0.1mg
EUR 1820

DNA/RNA Damage Antibody: APC
SMC-155D-APC 0.1mg
EUR 250.6
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: HRP
SMC-155D-HRP 0.1mg
EUR 241.5
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: RPE
SMC-155D-RPE 0.1mg
EUR 248.5
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (FITC)
abx443130-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: FITC
MBS803261-01mg 0.1mg
EUR 455

DNA/RNA Damage Antibody: FITC
MBS803261-5x01mg 5x0.1mg
EUR 1790

DNA/RNA Damage Antibody: FITC
SMC-155D-FITC 0.1mg
EUR 245
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (PerCP)
abx443972-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: PerCP
MBS802697-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: PerCP
MBS802697-5x01mg 5x0.1mg
EUR 1830

DNA/RNA Damage Antibody: PerCP
SMC-155D-PCP 0.1mg
EUR 250.6
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (Biotin)
abx442850-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: Biotin
MBS803145-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Biotin
MBS803145-5x01mg 5x0.1mg
EUR 1815

DNA/RNA Damage Antibody: Biotin
SMC-155D-BI 0.1mg
EUR 247.8
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (ATTO390)
abx440040-200g 200 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO488)
abx440321-100g 100 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO594)
abx440883-100g 100 µg
EUR 587.5

DNA/RNA Damage Antibody: ATTO 594
MBS800732-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 594
MBS800732-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody: ATTO 390
MBS802627-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 390
MBS802627-5x01mg 5x0.1mg
EUR 1840

DNA/RNA Damage Antibody: ATTO 488
MBS804277-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 488
MBS804277-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody: ATTO 390
SMC-155D-A390 0.1mg
EUR 252
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: ATTO 488
SMC-155D-A488 0.1mg
EUR 251.3
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: ATTO 594
SMC-155D-A594 0.1mg
EUR 251.3
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody, Clone 15A3
SMC-155C 0.025mg
EUR 144
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

OASE00080-25UG - DNA/RNA Damage Antibody
OASE00080-25UG 25ug
EUR 199

OASE00081-100UG - DNA/RNA Damage Antibody
OASE00081-100UG 100ug
EUR 399

DNA/RNA Damage Antibody: Alkaline Phosphatase
MBS800170-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Alkaline Phosphatase
MBS800170-5x01mg 5x0.1mg
EUR 1800

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A565 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A633 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A655 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A680 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A700 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-APCCY7 0.1mg
EUR 540
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY350 0.1mg
EUR 471.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY405 0.1mg
EUR 457.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY488 0.1mg
EUR 445.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY594 0.1mg
EUR 447.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY633 0.1mg
EUR 441.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-P594 0.1mg
EUR 462
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-STR 0.1mg
EUR 451.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin.

8-OHdG (DNA/RNA Damage) polyclonal antibody
BS66180 50ul
EUR 358
Description: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

DNA/RNA Damage Antibody, Clone 15A3: Alkaline Phosphatase
SMC-155D-ALP 0.1mg
EUR 352
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase.

DNA/RNA Oxidative Damage
MBS605402-0025mg 0.025mg
EUR 455

DNA/RNA Oxidative Damage
MBS605402-01mg 0.1mg
EUR 675

DNA/RNA Oxidative Damage
MBS605402-5x01mg 5x0.1mg
EUR 2880

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503-100 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503-500 500ug
EUR 460

DNA and RNA Oxidative Damage Markers Monoclonal Antibody
MBS190121-01mg 0.1mg
EUR 425

DNA and RNA Oxidative Damage Markers Monoclonal Antibody
MBS190121-5x01mg 5x0.1mg
EUR 1900

Anti-8-hydroxyguanosine DNA/RNA Oxidative Damage Mouse Monoclonal Antibody
12501 100ug
EUR 380

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
AS10-708-100 100 µg
EUR 439

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
AS10-708-25 25 µg
EUR 223

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx002127-100l 100 µl
EUR 400

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx002127-20l 20 µl
EUR 175

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx002127-50l 50 µl
EUR 275

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx001528-100l 100 µl
EUR 400

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx001528-20l 20 µl
EUR 175

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx001528-50l 50 µl
EUR 275

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159468-100g 100 µg Ask for price

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159468-10g 10 µg
EUR 437.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159468-50g 50 µg Ask for price

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159469-100g 100 µg Ask for price

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159469-10g 10 µg
EUR 437.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159469-50g 50 µg Ask for price

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx338922-100l 100 µl
EUR 250

DNA Damage-Binding Protein 2 (DDB2) Antibody
20-abx338922
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  • 20 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx338922-50l 50 µl
EUR 162.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-100g 100 µg
EUR 362.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
20-abx333999
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  • Ask for price
  • 20 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-20g 20 µg
EUR 162.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-50g 50 µg
EUR 250

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx242438-96tests 96 tests
EUR 250

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx242444-96tests 96 tests
EUR 250

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx232284-100g 100 µg
EUR 350

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx232284-100ug 100 ug
EUR 577.2

DNA damage-binding protein 2 (DDB2) Antibody
abx402261-100tests 100 tests
EUR 287.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010557-100g 100 µg Ask for price

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010557-10g 10 µg
EUR 350

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010557-200g 200 µg Ask for price

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010559-100g 100 µg
EUR 387.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010559-10g 10 µg
EUR 300

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010559-200g 200 µg Ask for price

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx004988-100l 100 µl
EUR 400

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx004988
  • Ask for price
  • Ask for price
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  • Ask for price
  • 20 ul
  • 50 ul
  • 100 ul
  • 200 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx004988-20l 20 µl
EUR 175

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx004988-50l 50 µl
EUR 275

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-400l 400 µl
EUR 518.75

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-400ul 400 ul
EUR 627.6

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-80l 80 µl
EUR 281.25

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-400l 400 µl
EUR 518.75

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-400ul 400 ul
EUR 627.6

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-80l 80 µl
EUR 250

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx000607-100l 100 µl
EUR 400

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx000607
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  • Ask for price
  • 20 ul
  • 50 ul
  • 100 ul
  • 200 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx000607-20l 20 µl
EUR 175

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx000607-50l 50 µl
EUR 275

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx112119-100l 100 µl
EUR 612.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx112119
  • Ask for price
  • Ask for price
  • 50 ul
  • 150 ul

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx112120-100l 100 µl
EUR 612.5

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
20-abx112120
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  • Ask for price
  • 50 ul
  • 150 ul

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx123209-100l 100 µl
EUR 200

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
20-abx123209
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  • 20 ul
  • 50 ul
  • 100 ul
  • 200 ul

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx123209-1ml 1 ml
EUR 475

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx123209-200l 200 µl
EUR 325

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx129884-100l 100 µl
EUR 275

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx129884
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  • 10 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx129884-1ml 1 ml
EUR 775

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx129884-200l 200 µl
EUR 350

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx103576-100g 100 µg
EUR 750
about author

Nicolas

nicolas@corbettresearch.com

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