Tag Archive : antibodies in a sentence

corbettresearch

G-quadruplex DNA and RNA: Their roles in regulation of DNA replication and other biological functions

  • G-quadruplex is one of the best-studied non-B type DNA that is now known to be prevalently present in the genomes of almost all the biological species. Recent studies reveal roles of G-quadruplex (G4) structures in various nucleic acids and chromosome transactions.
  • In this short article, we will first describe recent findings on the roles of G4 in regulation of DNA replication. G4 is involved in regulation of spatio-temporal regulation of DNA replication through interaction with a specific binding protein, Rif1. This regulation is at least partially mediated by generation of specific chromatin architecture through Rif1-G4 interactions.
  • We will also describe recent studies showing the potential roles of G4 in initiation of DNA replication. Next, we will present showcases of highly diversified roles of DNA G4 and RNA G4 in regulation of nucleic acid and chromosome functions. Finally, we will discuss how the formation of cellular G4 could be regulated.
corbettresearch

corbettresearch

DNA / RNA Damage Antibody

abx440321-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx440602-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx440883-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx441164-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx441445-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx441726-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442007-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442288-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442569-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442850-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx443130-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx443410-100ug 100 ug
EUR 644.4

DNA / RNA Damage Antibody

abx443691-100ug 100 ug
EUR 678

DNA / RNA Damage Antibody

20-abx444884
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  • 100 ug
  • 25 ug

DNA / RNA Damage Antibody

abx443972-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444253-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444534-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444884-100l 100 µl
EUR 337.5

DNA/RNA Damage Antibody

MBS8001907-0025mg 0.025mg
EUR 265

DNA/RNA Damage Antibody

MBS8001907-5x0025mg 5x0.025mg
EUR 925

DNA/RNA Damage Antibody

MBS801590-01mg 0.1mg
EUR 415

DNA/RNA Damage Antibody

MBS801590-5x01mg 5x0.1mg
EUR 1595

DNA / RNA Damage Antibody (PE)

abx444253-100g 100 µg
EUR 575

DNA / RNA Damage Antibody (HRP)

abx443410-100g 100 µg
EUR 562.5

DNA/RNA Damage Antibody: HRP

MBS801864-01mg 0.1mg
EUR 450

DNA/RNA Damage Antibody: HRP

MBS801864-5x01mg 5x0.1mg
EUR 1770

DNA/RNA Damage Antibody: RPE

MBS803622-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: RPE

MBS803622-5x01mg 5x0.1mg
EUR 1820

DNA / RNA Damage Antibody (FITC)

abx443130-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: FITC

MBS803261-01mg 0.1mg
EUR 455

DNA/RNA Damage Antibody: FITC

MBS803261-5x01mg 5x0.1mg
EUR 1790

DNA / RNA Damage Antibody (PerCP)

abx443972-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: PerCP

MBS802697-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: PerCP

MBS802697-5x01mg 5x0.1mg
EUR 1830

DNA / RNA Damage Antibody (Biotin)

abx442850-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: Biotin

MBS803145-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Biotin

MBS803145-5x01mg 5x0.1mg
EUR 1815

DNA / RNA Damage Antibody (ATTO594)

abx440883-100g 100 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO390)

abx440040-200g 200 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO488)

abx440321-100g 100 µg
EUR 587.5

DNA/RNA Damage Antibody: ATTO 594

MBS800732-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 594

MBS800732-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody: ATTO 390

MBS802627-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 390

MBS802627-5x01mg 5x0.1mg
EUR 1840

DNA/RNA Damage Antibody: ATTO 488

MBS804277-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 488

MBS804277-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody, Clone 15A3

SMC-155C 0.025mg
EUR 144
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

DNA/RNA Damage Antibody, Clone 15A3

SMC-155D 0.1mg
EUR 306
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

DNA/RNA Damage Antibody, Clone 15A3

SMC-155S 0.012mg
EUR 44
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

OASE00080-25UG - DNA/RNA Damage Antibody

OASE00080-25UG 25ug
EUR 199

OASE00081-100UG - DNA/RNA Damage Antibody

OASE00081-100UG 100ug
EUR 399

DNA/RNA Damage Antibody: Alkaline Phosphatase

MBS800170-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Alkaline Phosphatase

MBS800170-5x01mg 5x0.1mg
EUR 1800

DNA/RNA Damage Antibody, Clone 15A3: HRP

SMC-155D-HRP 0.1mg
EUR 345
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with HRP.

DNA/RNA Damage Antibody, Clone 15A3: RPE

SMC-155D-RPE 0.1mg
EUR 355
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with RPE.

DNA/RNA Damage Antibody, Clone 15A3: FITC

SMC-155D-FITC 0.1mg
EUR 350
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with FITC.

DNA/RNA Damage Antibody, Clone 15A3: PerCP

SMC-155D-PCP 0.1mg
EUR 358
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PerCP.

DNA/RNA Damage Antibody, Clone 15A3: Biotin

SMC-155D-BI 0.1mg
EUR 354
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Biotin.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A565 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A633 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A655 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A680 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A700 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-APCCY7 0.1mg
EUR 540
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY350 0.1mg
EUR 471.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY405 0.1mg
EUR 457.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY488 0.1mg
EUR 445.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY594 0.1mg
EUR 447.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY633 0.1mg
EUR 441.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-P594 0.1mg
EUR 462
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-STR 0.1mg
EUR 451.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin.

DNA/RNA Damage Antibody, Clone 15A3: ATTO 390

SMC-155D-A390 0.1mg
EUR 360
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 390.

DNA/RNA Damage Antibody, Clone 15A3: ATTO 488

SMC-155D-A488 0.1mg
EUR 359
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 488.

DNA/RNA Damage Antibody, Clone 15A3: ATTO 594

SMC-155D-A594 0.1mg
EUR 359
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 594.

DNA/RNA Damage Antibody, Clone 15A3: Alkaline Phosphatase

SMC-155D-ALP 0.1mg
EUR 352
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase.

DNA/RNA Oxidative Damage

MBS605402-0025mg 0.025mg
EUR 455

DNA/RNA Oxidative Damage

MBS605402-01mg 0.1mg
EUR 675

DNA/RNA Oxidative Damage

MBS605402-5x01mg 5x0.1mg
EUR 2880

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody

12503 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody

12503-100 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody

12503-500 500ug
EUR 460

DNA and RNA Oxidative Damage Markers Monoclonal Antibody

MBS190121-01mg 0.1mg
EUR 425

DNA and RNA Oxidative Damage Markers Monoclonal Antibody

MBS190121-5x01mg 5x0.1mg
EUR 1900

Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (APC)

abx442602-100ug 100 ug
EUR 661.2

Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (APC)

abx442602-100g 100 µg
EUR 575

Anti-8-hydroxyguanosine DNA/RNA Oxidative Damage Mouse Monoclonal Antibody

12501 100ug
EUR 380

DNA Damage Inducible Transcript 3 (DDIT3) Polyclonal Antibody (Human), APC

4-PAJ282Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human DNA Damage Inducible Transcript 3 (DDIT3). This antibody is labeled with APC.

DNA Damage Inducible Transcript 3 (DDIT3) Polyclonal Antibody (Mouse), APC

4-PAJ282Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse DNA Damage Inducible Transcript 3 (DDIT3). This antibody is labeled with APC.

Damage Specific DNA Binding Protein 2 (DDB2) Polyclonal Antibody (Mouse), APC

4-PAA319Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Damage Specific DNA Binding Protein 2 (DDB2). This antibody is labeled with APC.

DNA Damage Inducible Transcript 3 (DDIT3) Polyclonal Antibody (Human), APC-Cy7

4-PAJ282Hu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human DNA Damage Inducible Transcript 3 (DDIT3). This antibody is labeled with APC-Cy7.

DNA Damage Inducible Transcript 3 (DDIT3) Polyclonal Antibody (Mouse), APC-Cy7

4-PAJ282Mu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse DNA Damage Inducible Transcript 3 (DDIT3). This antibody is labeled with APC-Cy7.

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081082-01mL 0.1mL
EUR 265

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081082-02mL 0.2mL
EUR 355

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081082-05mL 0.5mL
EUR 660

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081082-1mL 1mL
EUR 810

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081082-5mL 5mL
EUR 2330

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081088-01mL 0.1mL
EUR 275

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081088-02mL 0.2mL
EUR 365

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081088-05mL 0.5mL
EUR 675

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081088-1mL 1mL
EUR 835

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081088-5mL 5mL
EUR 2395

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2126555-01mL 0.1mL
EUR 285

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2126555-02mL 0.2mL
EUR 380

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2126555-05mL 0.5mL
EUR 710

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2126555-1mL 1mL
EUR 875

APC-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2126555-5mL 5mL
EUR 2525

Damage Specific DNA Binding Protein 2 (DDB2) Polyclonal Antibody (Human, Mouse), APC

4-PAA319Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Damage Specific DNA Binding Protein 2 (DDB2). This antibody is labeled with APC.

Damage Specific DNA Binding Protein 2 (DDB2) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA319Mu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Damage Specific DNA Binding Protein 2 (DDB2). This antibody is labeled with APC-Cy7.

APC-Linked Polyclonal Antibody to Damage Specific DNA Binding Protein 2 (DDB2)

MBS2041026-01mL 0.1mL
EUR 250

APC-Linked Polyclonal Antibody to Damage Specific DNA Binding Protein 2 (DDB2)

MBS2041026-02mL 0.2mL
EUR 320

APC-Linked Polyclonal Antibody to Damage Specific DNA Binding Protein 2 (DDB2)

MBS2041026-05mL 0.5mL
EUR 600

APC-Linked Polyclonal Antibody to Damage Specific DNA Binding Protein 2 (DDB2)

MBS2041026-1mL 1mL
EUR 730

APC-Linked Polyclonal Antibody to Damage Specific DNA Binding Protein 2 (DDB2)

MBS2041026-5mL 5mL
EUR 2095

APC-Linked Polyclonal Antibody to Damage Specific DNA Binding Protein 2 (DDB2)

MBS2041032-01mL 0.1mL
EUR 255

APC-Linked Polyclonal Antibody to Damage Specific DNA Binding Protein 2 (DDB2)

MBS2041032-02mL 0.2mL
EUR 330

APC-Linked Polyclonal Antibody to Damage Specific DNA Binding Protein 2 (DDB2)

MBS2041032-05mL 0.5mL
EUR 615

APC-Linked Polyclonal Antibody to Damage Specific DNA Binding Protein 2 (DDB2)

MBS2041032-1mL 1mL
EUR 755

APC-Linked Polyclonal Antibody to Damage Specific DNA Binding Protein 2 (DDB2)

MBS2041032-5mL 5mL
EUR 2160

APC/CY7-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081080-1mL 1mL
EUR 1185

APC/CY7-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081080-5mL 5mL
EUR 3445

APC/CY7-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081080-5x5mL 5x5mL
EUR 15495

APC/CY7-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081086-1mL 1mL
EUR 1220

APC/CY7-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081086-5mL 5mL
EUR 3540

APC/CY7-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2081086-5x5mL 5x5mL
EUR 15930

APC/Cy7-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2126553-1mL 1mL
EUR 1285

APC/Cy7-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2126553-5mL 5mL
EUR 3735

APC/Cy7-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3)

MBS2126553-5x5mL 5x5mL
EUR 16805

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)

AS10-708-100 100 µg
EUR 439

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)

AS10-708-25 25 µg
EUR 223

DNA Damage-Binding Protein 1 (DDB1) Antibody

abx232284-100ug 100 ug
EUR 577.2

DNA Damage-Binding Protein 1 (DDB1) Antibody

20-abx333999
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DNA Damage-Binding Protein 2 (DDB2) Antibody

20-abx338922
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Vaccination with Messenger RNA: A Promising Alternative to DNA Vaccination

  • The first proof-of-concept studies about the feasibility of genetic vaccines were published over three decades ago, opening the way for future development. The idea of nonviral antigen delivery had multiple advantages over the traditional live or inactivated pathogen-based vaccines, but a great deal of effort had to be invested to turn the idea of genetic vaccination into reality.
  • Although early proof-of-concept studies were groundbreaking, they also showed that numerous aspects of genetic vaccines needed to be improved. Until the early 2000s, the vast majority of effort was invested into the development of DNA vaccines due to the potential issues of instability and low in vivo translatability of messenger RNA (mRNA).
  • In recent years, numerous studies have demonstrated the outstanding abilities of mRNA to elicit potent immune responses against infectious pathogens and different types of cancer, making it a viable platform for vaccine development. Multiple mRNA vaccine platforms have been developed and evaluated in small and large animals and humans and the results seem to be promising. RNA-based vaccines have important advantages over other vaccine approaches including outstanding efficacy, safety, and the potential for rapid, inexpensive, and scalable production.
  • There is a substantial investment by new mRNA companies into the development of mRNA therapeutics, particularly vaccines, increasing the number of basic and translational research publications and human clinical trials underway. This review gives a broad overview about genetic vaccines and mainly focuses on the past and present of mRNA vaccines along with the future directions to bring this potent vaccine platform closer to therapeutic use.
Atypical structures of GAA/TTC trinucleotide repeats underlying Friedreich’s ataxia: DNA triplexes and RNA/DNA hybrids
Expansion of the GAA/TTC repeats in the first intron of the FXN gene causes Friedreich’s ataxia. Non-canonical structures are linked to this expansion. DNA triplexes and R-loops are believed to arrest transcription, which results in frataxin deficiency and eventual neurodegeneration.
We present a systematic in silico characterization of the possible DNA triplexes that could be assembled with GAA and TTC strands; the two hybrid duplexes [r(GAA):d(TTC) and d(GAA):r(UUC)] in an R-loop; and three hybrid triplexes that could form during bidirectional transcription when the non-template DNA strand bonds with the hybrid duplex (collapsed R-loops, where the two DNA strands remain antiparallel).
For both Y·R:Y and R·R:Y DNA triplexes, the parallel third strand orientation is more stable; both parallel and antiparallel protonated d(GA+A)·d(GAA):d(TTC) triplexes are stable. Apparent contradictions in the literature about the R·R:Y triplex stability is probably due to lack of molecular resolution, since shifting the third strand by a single nucleotide alters the stability ranking.
In the collapsed R-loops, antiparallel d(TTC+)·d(GAA):r(UUC) is unstable, while parallel d(GAA)·r(GAA):d(TTC) and d(GA+A)·r(GAA):d(TTC) are stable. In addition to providing new structural perspectives for specific therapeutic aims, our results contribute to a systematic structural basis for the emerging field of quantitative R-loop biology.

DNA / RNA Damage Antibody

abx440883-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx441164-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx441445-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx441726-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442007-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442288-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442569-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442850-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx443130-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx443410-100ug 100 ug
EUR 644.4

DNA / RNA Damage Antibody

abx443691-100ug 100 ug
EUR 678

DNA / RNA Damage Antibody

20-abx444884
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  • 100 ug
  • 25 ug

DNA / RNA Damage Antibody

abx443972-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444253-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444534-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444884-100l 100 µl
EUR 337.5

DNA/RNA Damage Antibody

MBS8001907-0025mg 0.025mg
EUR 265

DNA/RNA Damage Antibody

MBS8001907-5x0025mg 5x0.025mg
EUR 925

DNA/RNA Damage Antibody

MBS801590-01mg 0.1mg
EUR 415

DNA/RNA Damage Antibody

MBS801590-5x01mg 5x0.1mg
EUR 1595

DNA / RNA Damage Antibody (PE)

abx444253-100g 100 µg
EUR 575

DNA / RNA Damage Antibody (APC)

abx442569-100l 100 µl
EUR 575

DNA / RNA Damage Antibody (HRP)

abx443410-100g 100 µg
EUR 562.5

DNA/RNA Damage Antibody: HRP

MBS801864-01mg 0.1mg
EUR 450

DNA/RNA Damage Antibody: HRP

MBS801864-5x01mg 5x0.1mg
EUR 1770

DNA/RNA Damage Antibody: RPE

MBS803622-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: RPE

MBS803622-5x01mg 5x0.1mg
EUR 1820

DNA / RNA Damage Antibody (FITC)

abx443130-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: FITC

MBS803261-01mg 0.1mg
EUR 455

DNA/RNA Damage Antibody: FITC

MBS803261-5x01mg 5x0.1mg
EUR 1790

DNA / RNA Damage Antibody (PerCP)

abx443972-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: PerCP

MBS802697-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: PerCP

MBS802697-5x01mg 5x0.1mg
EUR 1830

DNA / RNA Damage Antibody (ATTO594)

abx440883-100g 100 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO390)

abx440040-200g 200 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO488)

abx440321-100g 100 µg
EUR 587.5

DNA/RNA Damage Antibody: ATTO 594

MBS800732-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 594

MBS800732-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody: ATTO 390

MBS802627-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 390

MBS802627-5x01mg 5x0.1mg
EUR 1840

DNA/RNA Damage Antibody: ATTO 488

MBS804277-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 488

MBS804277-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody, Clone 15A3

SMC-155C 0.025mg
EUR 144
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

DNA/RNA Damage Antibody, Clone 15A3

SMC-155D 0.1mg
EUR 306
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

DNA/RNA Damage Antibody, Clone 15A3

SMC-155S 0.012mg
EUR 44
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

DNA Damage-Binding Protein 1 (DDB1) Antibody (Biotin)

20-abx335378
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DNA Damage-Binding Protein 2 (DDB2) Antibody (Biotin)

20-abx335381
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DNA Damage-Binding Protein 1 (DDB1) Antibody (Biotin)

abx335378-100g 100 µg
EUR 362.5

DNA Damage-Binding Protein 1 (DDB1) Antibody (Biotin)

abx335378-20g 20 µg
EUR 162.5

DNA Damage-Binding Protein 1 (DDB1) Antibody (Biotin)

abx335378-50g 50 µg
EUR 250

DNA Damage-Binding Protein 2 (DDB2) Antibody (Biotin)

abx335381-100g 100 µg
EUR 362.5

DNA Damage-Binding Protein 2 (DDB2) Antibody (Biotin)

abx335381-20g 20 µg
EUR 162.5

DNA Damage-Binding Protein 2 (DDB2) Antibody (Biotin)

abx335381-50g 50 µg
EUR 250

OASE00080-25UG - DNA/RNA Damage Antibody

OASE00080-25UG 25ug
EUR 199

OASE00081-100UG - DNA/RNA Damage Antibody

OASE00081-100UG 100ug
EUR 399

DNA Damage Inducible Transcript 3 (DDIT3) Antibody (Biotin)

20-abx272570
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

DNA Damage Inducible Transcript 3 (DDIT3) Antibody (Biotin)

20-abx303607
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DNA Damage Inducible Transcript 3 (DDIT3) Antibody (Biotin)

abx303607-100g 100 µg
EUR 362.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody (Biotin)

abx303607-20g 20 µg
EUR 162.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody (Biotin)

abx303607-50g 50 µg
EUR 250

DNA Damage Inducible Transcript 3 (DDIT3) Antibody (Biotin)

abx272570-1ml 1 ml
EUR 825

DNA Damage Inducible Transcript 3 (DDIT3) Antibody (Biotin)

abx272570-200l 200 µl
EUR 362.5

DNA/RNA Damage Antibody: Alkaline Phosphatase

MBS800170-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Alkaline Phosphatase

MBS800170-5x01mg 5x0.1mg
EUR 1800

P53 And DNA Damage Regulated 1 (PDRG1) Antibody (Biotin)

20-abx311437
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

P53 And DNA Damage Regulated 1 (PDRG1) Antibody (Biotin)

abx311437-100g 100 µg
EUR 362.5

P53 And DNA Damage Regulated 1 (PDRG1) Antibody (Biotin)

abx311437-20g 20 µg
EUR 162.5

P53 And DNA Damage Regulated 1 (PDRG1) Antibody (Biotin)

abx311437-50g 50 µg
EUR 250

DNA/RNA Damage Antibody, Clone 15A3: APC

SMC-155D-APC 0.1mg
EUR 358
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC.

DNA/RNA Damage Antibody, Clone 15A3: HRP

SMC-155D-HRP 0.1mg
EUR 345
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with HRP.

DNA/RNA Damage Antibody, Clone 15A3: RPE

SMC-155D-RPE 0.1mg
EUR 355
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with RPE.

DNA/RNA Damage Antibody, Clone 15A3: FITC

SMC-155D-FITC 0.1mg
EUR 350
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with FITC.

DNA/RNA Damage Antibody, Clone 15A3: PerCP

SMC-155D-PCP 0.1mg
EUR 358
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PerCP.

Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (Biotin)

abx442882-100ug 100 ug
EUR 661.2

Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (Biotin)

20-abx316284
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (Biotin)

abx442882-100g 100 µg
EUR 575

Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (Biotin)

abx316284-100g 100 µg
EUR 362.5

Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (Biotin)

abx316284-20g 20 µg
EUR 162.5

Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody (Biotin)

abx316284-50g 50 µg
EUR 250

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A565 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A633 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A655 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A680 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A700 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-APCCY7 0.1mg
EUR 540
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY350 0.1mg
EUR 471.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY405 0.1mg
EUR 457.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY488 0.1mg
EUR 445.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY594 0.1mg
EUR 447.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY633 0.1mg
EUR 441.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-P594 0.1mg
EUR 462
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-STR 0.1mg
EUR 451.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin.

DNA Damage Inducible Transcript 4 Like (DDIT4L) Antibody (Biotin)

20-abx314619
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DNA Damage Inducible Transcript 4 Like (DDIT4L) Antibody (Biotin)

abx314619-100g 100 µg
EUR 362.5

DNA Damage Inducible Transcript 4 Like (DDIT4L) Antibody (Biotin)

abx314619-20g 20 µg
EUR 162.5

DNA Damage Inducible Transcript 4 Like (DDIT4L) Antibody (Biotin)

abx314619-50g 50 µg
EUR 250

DNA/RNA Damage Antibody, Clone 15A3: ATTO 390

SMC-155D-A390 0.1mg
EUR 360
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 390.

DNA/RNA Damage Antibody, Clone 15A3: ATTO 488

SMC-155D-A488 0.1mg
EUR 359
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 488.

DNA/RNA Damage Antibody, Clone 15A3: ATTO 594

SMC-155D-A594 0.1mg
EUR 359
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 594.

Growth Arrest And DNA Damage-Inducible, Alpha (GADD45A) Antibody (Biotin)

20-abx303924
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest And DNA Damage-Inducible, Alpha (GADD45A) Antibody (Biotin)

abx303924-100g 100 µg
EUR 362.5

Growth Arrest And DNA Damage-Inducible, Alpha (GADD45A) Antibody (Biotin)

abx303924-20g 20 µg
EUR 162.5
corbettresearch

Cell Cycle Checkpoints Cooperate to Suppress DNA– and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses

  • The DNA-dependent pattern recognition receptor, cGAS (cyclic GMP-AMP synthase), mediates communication between the DNA damage and the immune responses. Mitotic chromosome missegregation stimulates cGAS activity; however, it is unclear whether progression through mitosis is required for cancercell-intrinsic activation of anti-tumor immune responses.
  • Moreover, it is unknown whether cell cycle checkpoint disruption can restore responses in cancer cells that are recalcitrant to DNAdamage-induced inflammation. Here, we demonstrate that prolonged cell cycle arrest at the G2-mitosis boundary from either excessive DNA damage or CDK1 inhibition prevents inflammatory-stimulated gene expression and immune-mediated destruction of distal tumors. Remarkably, DNAdamage-induced inflammatory signaling is restored in a RIG-I-dependent manner upon concomitant disruption of p53 and the G2 checkpoint.
  • These findings link aberrant cell progression and p53 loss to an expanded spectrum of damage-associated molecular pattern recognition and have implications for the design of rational approaches to augment anti-tumor immune responses.
corbettresearch

corbettresearch

DNA and RNA Oxidative Damage Markers Monoclonal Antibody

MBS190121-5x01mg 5x0.1mg
EUR 1900

Anti-8-hydroxyguanosine DNA/RNA Oxidative Damage Mouse Monoclonal Antibody

12501 100ug
EUR 380

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)

AS10-708-100 100 µg
EUR 439

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)

AS10-708-25 25 µg
EUR 223

DNA Oxidative Damage Kit - Quantitative

DN-002 20 tests
EUR 656

OxiSelect™ Oxidative DNA Damage Quantitation Kit (AP sites)

STA-324 50 assays
EUR 695

OxiSelect Oxidative DNA Damage Quantitation Kit (AP Sites), Trial Size

STA-324-T 10 assays
EUR 498
Description: DNA damage can manifest in the formation of apurinic or apyrimidinic (AP or abasic) sites. Such spontaneous base loss in mammalian cells has been estimated at between 50,000 and 200,000 sites per day. Unrepaired abasic sites can inhibit transcription and may be mutagenic. Our OxiSelect Oxidative DNA Damage Quantitation Kit provides a simple, user-friendly method for the quantitaiton DNA damage in the form of abasic sites. The assay uses an Aldehyde Reactive Probe (ARP) to specifically react with an aldehyde group on the open ring of the AP site. This allows the AP site to be labeled with Biotin, followed by detection with Streptavidin-Enzyme conjugate.

OxiSelect Oxidative RNA Damage ELISA Kit (8-OHG Quantitation) (96 tests)

MBS168447-5x96Assays 5x96Assays
EUR 4465

OxiSelect Oxidative RNA Damage ELISA Kit (8-OHG Quantitation) (96 tests)

MBS168447-96Assays 96Assays
EUR 1125

OxiSelect Oxidative RNA Damage ELISA Kit (8-OHG Quantitation), Trial Size

STA-325-T 32 assays
EUR 609.6
Description: Recently oxidative RNA damage has been described in conjunction with a wide variety of neurological diseases including Alzheimer?s disease, Parkinson?s disease, Dementia with Lewy Bodies, prion disease, and subacute sclerosing panencephalitis. We have developed an easy-to-use ELISA for the detection of the most common marker of RNA damage: 8-hydroxyguanosine (8-OHG).

OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation) (1 plate)

MBS168191-32Assays 32Assays
EUR 615

OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation) (1 plate)

MBS168191-5x96Assays 5x96Assays
EUR 4465

OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation) (1 plate)

MBS168191-96Assays 96Assays
EUR 1125

OxiSelect™ Oxidative RNA Damage ELISA Kit (8-OHG Quantitation) (96 tests)

STA-325 96 assays
EUR 885

OxiSelect™ Oxidative RNA Damage ELISA Kit (8-OHG Quantitation) (5x96 tests)

STA-325-5 5 x 96 assays
EUR 3795

OxiSelect™ Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation) (1 plate)

STA-320 96 assays
EUR 885

OxiSelect™ Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation) (5 plates)

STA-320-5 5 x 96 assays
EUR 3795

OxiSelect™ Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation), Trial Size

STA-320-T 32 assays
EUR 440

DNA/RNA Damage Antibody, 15A3; Anti-DNA/RNA Damage Antibody

MBS802475-0025mg 0.025mg
EUR 265

DNA / RNA Damage Antibody

abx440040-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx440321-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx440602-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx440883-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx441164-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx441445-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx441726-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442007-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442288-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442569-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442850-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx443130-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx443410-100ug 100 ug
EUR 644.4

DNA / RNA Damage Antibody

abx443691-100ug 100 ug
EUR 678

DNA / RNA Damage Antibody

20-abx444884
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  • 100 ug
  • 25 ug

DNA / RNA Damage Antibody

abx443972-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444253-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444534-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444884-100l 100 µl
EUR 337.5

DNA/RNA Damage Antibody

MBS8001907-0025mg 0.025mg
EUR 265

DNA/RNA Damage Antibody

MBS8001907-5x0025mg 5x0.025mg
EUR 925

DNA/RNA Damage Antibody

MBS801590-01mg 0.1mg
EUR 415

DNA/RNA Damage Antibody

MBS801590-5x01mg 5x0.1mg
EUR 1595

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

abx148136-100ug 100 ug
EUR 526.8

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

20-abx005629
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

20-abx321453
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  • 100 ul
  • 50 ul

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

20-abx320325
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  • 100 ul
  • 50 ul

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

abx321453-100g 100 µg
EUR 350

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

abx321453-50g 50 µg
EUR 237.5

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

abx320325-100l 100 µl
EUR 350

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

abx320325-50l 50 µl
EUR 237.5

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

abx005629-100l 100 µl
EUR 175

DNA / RNA Damage Antibody (PE)

abx444253-100g 100 µg
EUR 575

DNA / RNA Damage Antibody (APC)

abx442569-100l 100 µl
EUR 575

DNA / RNA Damage Antibody (HRP)

abx443410-100g 100 µg
EUR 562.5

DNA/RNA Damage Antibody: HRP

MBS801864-01mg 0.1mg
EUR 450

DNA/RNA Damage Antibody: HRP

MBS801864-5x01mg 5x0.1mg
EUR 1770

DNA/RNA Damage Antibody: RPE

MBS803622-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: RPE

MBS803622-5x01mg 5x0.1mg
EUR 1820

DNA / RNA Damage Antibody (FITC)

abx443130-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: FITC

MBS803261-01mg 0.1mg
EUR 455

DNA/RNA Damage Antibody: FITC

MBS803261-5x01mg 5x0.1mg
EUR 1790

DNA / RNA Damage Antibody (PerCP)

abx443972-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: PerCP

MBS802697-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: PerCP

MBS802697-5x01mg 5x0.1mg
EUR 1830

DNA / RNA Damage Antibody (Biotin)

abx442850-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: Biotin

MBS803145-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Biotin

MBS803145-5x01mg 5x0.1mg
EUR 1815

DNA / RNA Damage Antibody (ATTO594)

abx440883-100g 100 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO390)

abx440040-200g 200 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO488)

abx440321-100g 100 µg
EUR 587.5

DNA/RNA Damage Antibody: ATTO 594

MBS800732-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 594

MBS800732-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody: ATTO 390

MBS802627-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 390

MBS802627-5x01mg 5x0.1mg
EUR 1840

DNA/RNA Damage Antibody: ATTO 488

MBS804277-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 488

MBS804277-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody, Clone 15A3

SMC-155C 0.025mg
EUR 144
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

DNA/RNA Damage Antibody, Clone 15A3

SMC-155D 0.1mg
EUR 306
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

DNA/RNA Damage Antibody, Clone 15A3

SMC-155S 0.012mg
EUR 44
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

OASE00080-25UG - DNA/RNA Damage Antibody

OASE00080-25UG 25ug
EUR 199

OASE00081-100UG - DNA/RNA Damage Antibody

OASE00081-100UG 100ug
EUR 399

DNA/RNA Damage Antibody: Alkaline Phosphatase

MBS800170-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Alkaline Phosphatase

MBS800170-5x01mg 5x0.1mg
EUR 1800

DNA/RNA Damage Antibody, Clone 15A3: APC

SMC-155D-APC 0.1mg
EUR 358
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC.

DNA/RNA Damage Antibody, Clone 15A3: HRP

SMC-155D-HRP 0.1mg
EUR 345
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with HRP.

DNA/RNA Damage Antibody, Clone 15A3: RPE

SMC-155D-RPE 0.1mg
EUR 355
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with RPE.

DNA/RNA Damage Antibody, Clone 15A3: FITC

SMC-155D-FITC 0.1mg
EUR 350
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with FITC.

DNA/RNA Damage Antibody, Clone 15A3: PerCP

SMC-155D-PCP 0.1mg
EUR 358
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PerCP.

DNA/RNA Damage Antibody, Clone 15A3: Biotin

SMC-155D-BI 0.1mg
EUR 354
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Biotin.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A565 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A633 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A655 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A680 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A700 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-APCCY7 0.1mg
EUR 540
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY350 0.1mg
EUR 471.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY405 0.1mg
EUR 457.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY488 0.1mg
EUR 445.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY594 0.1mg
EUR 447.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY633 0.1mg
EUR 441.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-P594 0.1mg
EUR 462
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-STR 0.1mg
EUR 451.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin.

DNA/RNA Damage Antibody, Clone 15A3: ATTO 390

SMC-155D-A390 0.1mg
EUR 360
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 390.

DNA/RNA Damage Antibody, Clone 15A3: ATTO 488

SMC-155D-A488 0.1mg
EUR 359
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 488.

DNA/RNA Damage Antibody, Clone 15A3: ATTO 594

SMC-155D-A594 0.1mg
EUR 359
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 594.

DNA/RNA Damage Antibody, Clone 15A3: Alkaline Phosphatase

SMC-155D-ALP 0.1mg
EUR 352
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase.

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx114290-100l 100 µl
EUR 612.5

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx212012-100l 100 µl
EUR 350

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx212012-50l 50 µl
EUR 250

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx213481-10l 10 µl
EUR 250

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx236055-100g 100 µg
EUR 350

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx146245-1096tests 10 × 96 tests Ask for price

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx146245-596tests 5 × 96 tests Ask for price

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx146245-96tests 96 tests
EUR 337.5

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx325277-100g 100 µg
EUR 250

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx325277-50g 50 µg
EUR 187.5

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx325602-100g 100 µg
EUR 250

Oxidative Stress Responsive 1 (OXSR1) Antibody

abx325602-50g 50 µg
EUR 187.5

Human DNA Oxidative Demethylase ALKBH2 (ALKBH2) Protein

abx073206-20kDa1g 20 kDa; 1 g
EUR 225

Human DNA Oxidative Demethylase ALKBH2 (ALKBH2) Protein

abx073206-20kDa5g 20 kDa; 5 g
EUR 3550

Human DNA Oxidative Demethylase ALKBH2 (ALKBH2) Protein

abx073206-40kDa1g 40 kDa; 1 g
EUR 325

Oxidative-Stress Responsive 1 (OXSR1) Antibody

20-abx114290
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  • 150 ul
  • 50 ul

Recombinant Human DNA oxidative demethylase ALKBH2 (ALKBH2)

CSB-EP761219HU 4107 mg Ask for price

Oxidative Stress Antibodies Set | 5 antibodies

AS19-4294 each
EUR 1472

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody

12503 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody

12503-100 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody

12503-500 500ug
EUR 460

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

20-abx128290
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  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx146030-100ug 100 ug
EUR 469.2

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

20-abx114289
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx029975-400ul 400 ul
EUR 627.6

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx029975-80l 80 µl
EUR 343.2

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx236027-100ug 100 ug
EUR 610.8

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

20-abx173928
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx114289-100l 100 µl
EUR 612.5

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx128290-100l 100 µl
EUR 275

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx128290-1ml 1 ml
EUR 750

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx128290-200l 200 µl
EUR 337.5

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx173928-100l 100 µl
EUR 787.5

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx173928-1ml 1 ml Ask for price

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx173928-200l 200 µl Ask for price

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx029975-400l 400 µl
EUR 518.75

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx236027-100g 100 µg
EUR 350

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx146030-1096tests 10 × 96 tests Ask for price

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx146030-596tests 5 × 96 tests Ask for price

Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody

abx146030-96tests 96 tests
EUR 337.5

Human Oxidative Stress-Responsive 1 Protein (OXSR1) Antibody

33219-05111 150 ug
EUR 215

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody

abx122927-100ug 100 ug
EUR 469.2

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody

20-abx302885
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  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody

abx122927-100l 100 µl Ask for price

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody

abx122927-20l 20 µl
EUR 337.5

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody

abx122927-50l 50 µl Ask for price

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody

abx302885-100g 100 µg
EUR 362.5

Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody

abx302885-20g 20 µg
EUR 162.5

A G-quadruplex-forming RNA aptamer binds to the MTG8 TAFH domain and dissociates the leukemic AML1-MTG8 fusion protein from DNA

MTG8 (RUNX1T1) is a fusion partner of AML1 (RUNX1) in the leukemic chromosome translocation t(8;21). The AML1-MTG8 fusion gene encodes a chimeric transcription factor. One of the highly conserved domains of MTG8 is TAFH which possesses homology with human TAF4 [TATA-box binding protein (TBP)-associated factor].
To obtain specific inhibitors of the AML1-MTG8 fusion protein, we isolated RNA aptamers against the MTG8 TAFH domain using Systematic Evolution of Ligands by EXponential enrichment (SELEX). All TAF aptamers contained guanine-rich sequences. Analyses of a TAF aptamer by NMR, CD and mutagenesis revealed that it forms a parallel G-quadruplex structure in the presence of K+ .
Furthermore, the aptamer could bind to the AML1-MTG8 fusion protein and dissociate the AML1-MTG8/DNA complex, suggesting that it can inhibit the dominant negative effects of AML1-MTG8 against normal AML1 function and serve as a potential therapeutic agent for leukemia.

DNARNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing

Heteroduplex oligonucleotides (HDOs) were a novel type of nucleic acid drugs based on an antisense oligonucleotide (ASO) strand and its complementary RNA (cRNA ) strand.
HDOs were originally designed to improve the properties of RNase H-dependent ASOs and we reported in our first paper that HDOs conjugated with an α-tocopherol ligand (Toc-HDO ) based on a gapmer ASO showed 20 times higher silencing effect to liver apolipoprotein B (apoB) mRNA in vivo than the parent ASO.
Thereafter the HDO strategy was found to be also effective for improving the properties of ASOs modulating blood-brain barrier function and ASO antimiRs which are RNase H-independent ASOs. Therefore, the HDO strategy has been shown to be versatile technology platform to develop effective nucleic acid drugs.

Site-selective RNA Functionalization via DNA-induced Structure

Methods for RNA functionalization at specific sites are in high demand, but remain a challenge, particularly for RNAs produced by transcription rather than by total synthesis. Recent studies have described acylimidazole reagents that react in high yields at 2′-OH groups stochastically at non-base-paired regions, covering much of the RNA in scattered acyl esters.
Localized reactions, if possible, could prove useful in many applications, providing functional handles at specific sites and sequences of the biopolymer. Here we describe a DNA-directed strategy for in vitro functionalization of RNA at site-localized 2′-OH groups. The method, RNA Acylation at Induced Loops (RAIL), utilizes complementary helper DNA oligonucleotides that expose gaps or loops at selected positions while protecting the remainder in DNA-RNA duplexes.
Reaction with an acylimidazole reagent is then carried out, providing high yields of 2′-OH conjugation at predetermined sites. Experiments reveal optimal helper oligodeoxynucleotide designs and conditions for the reaction, and tests of the approach are carried out to control localized ribozyme activities and to label RNAs with dual-color fluorescent dyes. The RAIL approach offers a simple and novel strategy for site-specific labeling and control of RNAs, potentially of any length and origin.

Optimization of a Method for the Simultaneous Extraction of Polar and Non-Polar Oxylipin Metabolites, DNARNA, Small RNA, and Protein from a Single Small Tissue Sample

A more comprehensive picture of tissue biology can be obtained through the application and integration of multiple omic technologies. However, the common challenge in working with a precious sample is having a sample too small to separately extract analytes of interest for each experiment. Considering the high heterogeneity that can be present in a single tissue sample, extracting all biomolecules from a single and undivided tissue is preferable because it allows direct comparison of results.
Here, we combined a modified Folch extraction method with DNA, RNA, small RNA, and protein extraction using two commercial kits, which allowed us to extract polar metabolites and non-polar oxylipin metabolites, DNA, RNA, small RNA, and protein simultaneously from a small tissue sample. The method was validated in terms of quantity and quality of analytes for downstream analyses.

DNA / RNA Damage Antibody

abx441445-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx441726-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442007-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442288-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442569-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx442850-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx443130-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx443410-100ug 100 ug
EUR 644.4

DNA / RNA Damage Antibody

abx443691-100ug 100 ug
EUR 678

DNA / RNA Damage Antibody

20-abx444884
  • Ask for price
  • Ask for price
  • 100 ug
  • 25 ug

DNA / RNA Damage Antibody

abx443972-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444253-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444534-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody

abx444884-100l 100 µl
EUR 337.5

DNA/RNA Damage Antibody

MBS8001907-0025mg 0.025mg
EUR 265

DNA/RNA Damage Antibody

MBS8001907-5x0025mg 5x0.025mg
EUR 925

DNA/RNA Damage Antibody

MBS801590-01mg 0.1mg
EUR 415

DNA/RNA Damage Antibody

MBS801590-5x01mg 5x0.1mg
EUR 1595

DNA / RNA Damage Antibody (PE)

abx444253-100g 100 µg
EUR 575

DNA / RNA Damage Antibody (APC)

abx442569-100l 100 µl
EUR 575

DNA / RNA Damage Antibody (HRP)

abx443410-100g 100 µg
EUR 562.5

DNA/RNA Damage Antibody: HRP

MBS801864-01mg 0.1mg
EUR 450

DNA/RNA Damage Antibody: HRP

MBS801864-5x01mg 5x0.1mg
EUR 1770

DNA/RNA Damage Antibody: RPE

MBS803622-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: RPE

MBS803622-5x01mg 5x0.1mg
EUR 1820

DNA / RNA Damage Antibody (FITC)

abx443130-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: FITC

MBS803261-01mg 0.1mg
EUR 455

DNA/RNA Damage Antibody: FITC

MBS803261-5x01mg 5x0.1mg
EUR 1790

DNA / RNA Damage Antibody (PerCP)

abx443972-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: PerCP

MBS802697-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: PerCP

MBS802697-5x01mg 5x0.1mg
EUR 1830

DNA / RNA Damage Antibody (Biotin)

abx442850-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: Biotin

MBS803145-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Biotin

MBS803145-5x01mg 5x0.1mg
EUR 1815

DNA / RNA Damage Antibody (ATTO594)

abx440883-100g 100 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO390)

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