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G-quadruplex DNA and RNA: Their roles in regulation of DNA replication and other biological functions G-quadruplex is one of the best-studied non-B type DNA that is now known to be prevalently present in the genomes of almost all the biological species. Recent studies reveal roles of G-quadruplex (G4) structures in various nucleic acids and chromosome…

The role of active-site amino acid residues in the cleavage of DNA and RNA substrates by human apurinic/apyrimidinic endonuclease APE1 Background: Human apurinic/apyrimidinic endonuclease APE1 is one of participants of the DNA base excision repair pathway. APE1 processes AP-sites and many other types of DNA damage via hydrolysis of the phosphodiester bond on the 5′…

Cell Cycle Checkpoints Cooperate to Suppress DNA– and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses The DNA-dependent pattern recognition receptor, cGAS (cyclic GMP-AMP synthase), mediates communication between the DNA damage and the immune responses. Mitotic chromosome missegregation stimulates cGAS activity; however, it is unclear whether progression through mitosis is required for…

EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data Cell type heterogeneity presents a challenge to the interpretation of epigenome data, compounded by the difficulty in generating reliable single-cell DNA methylomes for large numbers of cells and samples. We present EPISCORE, a computational algorithm that performs virtual microdissection of…

Mechanisms for goal recognition and cleavage by the Cas12i RNA-guided endonuclease Cas12i is a lately recognized kind V CRISPR-Cas endonuclease that predominantly cleaves the non-target strand of a double-stranded DNA substrate. This nicking exercise of Cas12i may probably be used for genome enhancing with excessive specificity. To elucidate its mechanisms for…