Suppliers for Lab reagents Our used rec. in Pubmed.
29
Dec
29
Dec
Suppliers for Lab polyclonals Our used polyclonals in Pubmed.
28
Dec
Promoted Lab antibodies Our used antibodies in Pubmed.
10
Sep
G-quadruplex DNA and RNA: Their roles in regulation of DNA replication and other biological functions G-quadruplex is one of the best-studied non-B type DNA that is now known to be prevalently present in the genomes of almost all the biological species. Recent studies reveal roles of G-quadruplex (G4) structures in various nucleic acids and chromosome…
10
Sep
The role of active-site amino acid residues in the cleavage of DNA and RNA substrates by human apurinic/apyrimidinic endonuclease APE1 Background: Human apurinic/apyrimidinic endonuclease APE1 is one of participants of the DNA base excision repair pathway. APE1 processes AP-sites and many other types of DNA damage via hydrolysis of the phosphodiester bond on the 5′…
10
Sep
Cell Cycle Checkpoints Cooperate to Suppress DNA– and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses The DNA-dependent pattern recognition receptor, cGAS (cyclic GMP-AMP synthase), mediates communication between the DNA damage and the immune responses. Mitotic chromosome missegregation stimulates cGAS activity; however, it is unclear whether progression through mitosis is required for…
10
Sep
EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data Cell type heterogeneity presents a challenge to the interpretation of epigenome data, compounded by the difficulty in generating reliable single-cell DNA methylomes for large numbers of cells and samples. We present EPISCORE, a computational algorithm that performs virtual microdissection of…
9
Sep
Mechanisms for goal recognition and cleavage by the Cas12i RNA-guided endonuclease Cas12i is a lately recognized kind V CRISPR-Cas endonuclease that predominantly cleaves the non-target strand of a double-stranded DNA substrate. This nicking exercise of Cas12i may probably be used for genome enhancing with excessive specificity. To elucidate its mechanisms for…