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corbettresearch
10 Sep

The role of active-site amino acid residues in the cleavage of DNA and RNA

By Nicolas Antibodies , Enzymes , Exosomes , Gels , PCR , Western Blot , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , No Comments

The role of active-site amino acid residues in the cleavage of DNA and RNA substrates by human apurinic/apyrimidinic endonuclease APE1

  • Background: Human apurinic/apyrimidinic endonuclease APE1 is one of participants of the DNA base excision repair pathway. APE1 processes AP-sites and many other types of DNA damage via hydrolysis of the phosphodiester bond on the 5′ side of the lesion. APE1 also acts as an endoribonuclease, i.e., can cleave undamaged RNA.
  • Methods: Using pre-steady-state kinetic analysis we examined the role of certain catalytically important amino acids in APE1 enzymatic pathway and described their involvement in the mechanism of the target nucleotide recognition.
  • Results: Comparative analysis of the cleavage efficiency of damaged DNAs containing an abasic site, 5,6-dihydrouridine, or α-anomer of adenosine as well as 3′-5′-exonuclease degradation of undamaged DNA and endonuclease hydrolysis of RNA substrates by mutant APE1 enzymes containing a substitution of an active-site amino acid residue (D210N, N212A, T268D, M270A, or D308A) was performed. Detailed pre-steady-state kinetics of conformational changes of the enzyme and of DNA substrate molecules during recognition and cleavage of the abasic site were studied.
  • Conclusions: It was revealed that substitution T268D significantly disturbed initial DNA binding, whereas Asn212 is critical for the DNA-bending stage and catalysis. Substitution D210N increased the binding efficacy and blocked the catalytic reaction, but D308A decreased the binding efficacy owing to disruption of Mg2+ coordination. Finally, the substitution of Met270 also destabilized the enzyme-substrate complex but did not affect the catalytic reaction.
General significance: It was found that the tested substitutions of the active-site amino acid residues affected different stages of the complex formation process as well as the catalytic reaction.
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Description: The Biolipidure-206 Reagent is a synthetic amphoteric polymer that can be substituted for BSA. Biolipidure-206 enhances signal strength, functions as an effective blocker, and stabilizes proteins and antibodies in ELISAs, EIAs, and related immunoassays. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Biolipidure-206-Reagent
Biolipidure-206-100 100mL
EUR 1467.6
Description: The Biolipidure-206 Reagent is a synthetic amphoteric polymer that can be substituted for BSA. Biolipidure-206 enhances signal strength, functions as an effective blocker, and stabilizes proteins and antibodies in ELISAs, EIAs, and related immunoassays. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Biolipidure-405-Reagent
Biolipidure-405-10 10mL
EUR 235.2
Description: The Biolipidure-405 Reagent is a synthetic anionic polymer that can be used to enhance immunochromatographic assays. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Biolipidure-405-Reagent
Biolipidure-405-100 100mL
EUR 1467.6
Description: The Biolipidure-405 Reagent is a synthetic anionic polymer that can be used to enhance immunochromatographic assays. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Biolipidure-502-Reagent
Biolipidure-502-10 10mL
EUR 235.2
Description: The Biolipidure-502 Reagent is a synthetic cationic polymer. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Biolipidure-502-Reagent
Biolipidure-502-100 100mL
EUR 1467.6
Description: The Biolipidure-502 Reagent is a synthetic cationic polymer. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Biolipidure-702-Reagent
Biolipidure-702-10 10mL
EUR 235.2
Description: The Biolipidure-702 Reagent is a synthetic amphoteric polymer. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Biolipidure-702-Reagent
Biolipidure-702-100 100mL
EUR 1467.6
Description: The Biolipidure-702 Reagent is a synthetic amphoteric polymer. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Biolipidure-802-Reagent
Biolipidure-802-10 10mL
EUR 235.2
Description: The Biolipidure-802 Reagent is a synthetic amphoteric polymer that can be substituted for BSA. Biolipidure-802 generally enhances signal strength, functions as an effective blocker, and stabilizes proteins and antibodies in ELISAs, EIAs, Rapid-test, and related immunoassays. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors

There are few methods available for the rapid discovery of multi-target drugs. Herein, we describe the template-assisted, target-guided discovery of small molecules that recognize d(CTG) in the expanded d(CTG·CAG) sequence and the r(CUG) transcript that cause myotonic dystrophy type 1 (DM1).
A positive cross-selection was performed using a small library of 30 monomeric alkyne- and azide-containing ligands capable of producing more than 5000 possible di- and trimeric click products. The monomers were incubated with d(CTG)16 or r(CUG)16 under physiological conditions and both sequences showed selectivity in the proximity-accelerated azide-alkyne [3+2]-cycloaddition click reaction.
The limited number of click products formed in both selections and the even smaller number of common products suggests that this method is a useful tool for the discovery of single-target and multi-target lead therapeutic agents.

CRISPR-Mediated Depletion of Ribosomal RNA-Derived DNA from RNA-Seq NGS Libraries

Although messenger RNA (mRNA) is the focus of much RNA research, it constitutes a relatively small fraction of total RNA in a cell. Most cellular RNA is ribosomal RNA (rRNA) and removal of this RNA is is desirable in many RNA-Seq studies in order to maximize capacity of the sequencing instrument and reduce costs.
We have employed the CRISPR Cas9 double-stranded DNA endonuclease to develop a different method of rRNA removal for RNA-Seq studies. Here we show data from the CRISPR treatment of rRNA sequences from RNA-Seq libraries prepared from three different bacteria and Homo sapiens.

DNA/RNA Electrochemical Biosensing Devices a Future Replacement of PCR Methods for a Fast Epidemic Containment

Pandemics require a fast and immediate response to contain potential infectious carriers. In the recent 2020 Covid-19 worldwide pandemic, authorities all around the world have failed to identify potential carriers and contain it on time. Hence, a rapid and very sensitive testing method is required.
Current diagnostic tools, reverse transcription PCR (RT-PCR) and real-time PCR (qPCR), have its pitfalls for quick pandemic containment such as the requirement for specialized professionals and instrumentation. Versatile electrochemical DNA/RNA sensors are a promising technological alternative for PCR based diagnosis. In an electrochemical DNA sensor, a nucleic acid hybridization event is converted into a quantifiable electrochemical signal.
A critical challenge of electrochemical DNA sensors is sensitive detection of a low copy number of DNA/RNA in samples such as is the case for early onset of a disease. Signal amplification approaches are an important tool to overcome this sensitivity issue. In this review, the authors discuss the most recent signal amplification strategies employed in the electrochemical DNA/RNA diagnosis of pathogens.

DNA / RNA Damage Antibody
abx441164-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx441445-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx441726-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx442007-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx442288-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx443130-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx443410-100ug 100 ug
EUR 644.4

DNA / RNA Damage Antibody
abx443691-100ug 100 ug
EUR 678

DNA / RNA Damage Antibody
abx443972-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx444253-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx442569-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx442850-100ug 100 ug
EUR 661.2

DNA/RNA Damage Antibody
MBS801590-01mg 0.1mg
EUR 415

DNA/RNA Damage Antibody
MBS801590-5x01mg 5x0.1mg
EUR 1595

DNA/RNA Damage Antibody
MBS8001907-0025mg 0.025mg
EUR 265

DNA/RNA Damage Antibody
MBS8001907-5x0025mg 5x0.025mg
EUR 925

DNA/RNA Damage Antibody
SMC-155D 0.1mg
EUR 214.2
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody
SMC-155S 0.012mg Ask for price
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (PE)
abx444253-100g 100 µg
EUR 575

DNA / RNA Damage Antibody (HRP)
abx443410-100g 100 µg
EUR 562.5

DNA / RNA Damage Antibody (APC)
abx442569-100l 100 µl
EUR 575

DNA/RNA Damage Antibody: RPE
MBS803622-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: RPE
MBS803622-5x01mg 5x0.1mg
EUR 1820

DNA/RNA Damage Antibody: HRP
MBS801864-01mg 0.1mg
EUR 450

DNA/RNA Damage Antibody: HRP
MBS801864-5x01mg 5x0.1mg
EUR 1770

DNA/RNA Damage Antibody: APC
SMC-155D-APC 0.1mg
EUR 250.6
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: HRP
SMC-155D-HRP 0.1mg
EUR 241.5
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: RPE
SMC-155D-RPE 0.1mg
EUR 248.5
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (FITC)
abx443130-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: FITC
MBS803261-01mg 0.1mg
EUR 455

DNA/RNA Damage Antibody: FITC
MBS803261-5x01mg 5x0.1mg
EUR 1790

DNA/RNA Damage Antibody: FITC
SMC-155D-FITC 0.1mg
EUR 245
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (PerCP)
abx443972-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: PerCP
MBS802697-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: PerCP
MBS802697-5x01mg 5x0.1mg
EUR 1830

DNA/RNA Damage Antibody: PerCP
SMC-155D-PCP 0.1mg
EUR 250.6
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (Biotin)
abx442850-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: Biotin
MBS803145-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Biotin
MBS803145-5x01mg 5x0.1mg
EUR 1815

DNA/RNA Damage Antibody: Biotin
SMC-155D-BI 0.1mg
EUR 247.8
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (ATTO390)
abx440040-200g 200 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO488)
abx440321-100g 100 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO594)
abx440883-100g 100 µg
EUR 587.5

DNA/RNA Damage Antibody: ATTO 488
MBS804277-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 488
MBS804277-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody: ATTO 594
MBS800732-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 594
MBS800732-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody: ATTO 390
MBS802627-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 390
MBS802627-5x01mg 5x0.1mg
EUR 1840

DNA/RNA Damage Antibody: ATTO 390
SMC-155D-A390 0.1mg
EUR 252
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: ATTO 488
SMC-155D-A488 0.1mg
EUR 251.3
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: ATTO 594
SMC-155D-A594 0.1mg
EUR 251.3
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody, Clone 15A3
SMC-155C 0.025mg
EUR 144
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

OASE00080-25UG - DNA/RNA Damage Antibody
OASE00080-25UG 25ug
EUR 199

OASE00081-100UG - DNA/RNA Damage Antibody
OASE00081-100UG 100ug
EUR 399

DNA/RNA Damage Antibody: Alkaline Phosphatase
MBS800170-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Alkaline Phosphatase
MBS800170-5x01mg 5x0.1mg
EUR 1800

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A565 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A633 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A655 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A680 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A700 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-APCCY7 0.1mg
EUR 540
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY350 0.1mg
EUR 471.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY405 0.1mg
EUR 457.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY488 0.1mg
EUR 445.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY594 0.1mg
EUR 447.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY633 0.1mg
EUR 441.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-P594 0.1mg
EUR 462
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-STR 0.1mg
EUR 451.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin.

8-OHdG (DNA/RNA Damage) polyclonal antibody
BS66180 50ul
EUR 358
Description: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

DNA/RNA Damage Antibody, Clone 15A3: Alkaline Phosphatase
SMC-155D-ALP 0.1mg
EUR 352
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase.

DNA/RNA Oxidative Damage
MBS605402-0025mg 0.025mg
EUR 455

DNA/RNA Oxidative Damage
MBS605402-01mg 0.1mg
EUR 675

DNA/RNA Oxidative Damage
MBS605402-5x01mg 5x0.1mg
EUR 2880

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503-100 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503-500 500ug
EUR 460

DNA and RNA Oxidative Damage Markers Monoclonal Antibody
MBS190121-01mg 0.1mg
EUR 425

DNA and RNA Oxidative Damage Markers Monoclonal Antibody
MBS190121-5x01mg 5x0.1mg
EUR 1900

Anti-8-hydroxyguanosine DNA/RNA Oxidative Damage Mouse Monoclonal Antibody
12501 100ug
EUR 380

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
AS10-708-100 100 µg
EUR 439

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
AS10-708-25 25 µg
EUR 223

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx002127-100l 100 µl
EUR 400

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx002127-20l 20 µl
EUR 175

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx002127-50l 50 µl
EUR 275

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx001528-100l 100 µl
EUR 400

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx001528-20l 20 µl
EUR 175

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx001528-50l 50 µl
EUR 275

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx242438-96tests 96 tests
EUR 250

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx242444-96tests 96 tests
EUR 250

DNA damage-binding protein 2 (DDB2) Antibody
abx402261-100tests 100 tests
EUR 287.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159468-100g 100 µg Ask for price

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159468-10g 10 µg
EUR 437.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159468-50g 50 µg Ask for price

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159469-100g 100 µg Ask for price

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159469-10g 10 µg
EUR 437.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159469-50g 50 µg Ask for price

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx338922-100l 100 µl
EUR 250

DNA Damage-Binding Protein 2 (DDB2) Antibody
20-abx338922
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 20 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx338922-50l 50 µl
EUR 162.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-100g 100 µg
EUR 362.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
20-abx333999
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 20 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-20g 20 µg
EUR 162.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-50g 50 µg
EUR 250

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx232284-100g 100 µg
EUR 350

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx232284-100ug 100 ug
EUR 577.2

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx000607-100l 100 µl
EUR 400

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx000607
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 20 ul
  • 50 ul
  • 100 ul
  • 200 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx000607-20l 20 µl
EUR 175

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx000607-50l 50 µl
EUR 275

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx004988-100l 100 µl
EUR 400

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx004988
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 20 ul
  • 50 ul
  • 100 ul
  • 200 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx004988-20l 20 µl
EUR 175

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx004988-50l 50 µl
EUR 275

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx032764-400l 400 µl
EUR 518.75

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx032764-80l 80 µl
EUR 281.25

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-400l 400 µl
EUR 518.75

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-400ul 400 ul
EUR 627.6

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-80l 80 µl
EUR 281.25

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-400l 400 µl
EUR 518.75

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-400ul 400 ul
EUR 627.6

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-80l 80 µl
EUR 250

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010557-100g 100 µg Ask for price

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010557-10g 10 µg
EUR 350

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010557-200g 200 µg Ask for price

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010559-100g 100 µg
EUR 387.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010559-10g 10 µg
EUR 300

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010559-200g 200 µg Ask for price

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx213754-100l 100 µl
EUR 250

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
20-abx213754
  • Ask for price
  • Ask for price
  • 50 ul
  • 100 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx301173-100g 100 µg
EUR 362.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx301173
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 20 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx301173-20g 20 µg
EUR 162.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx301173-50g 50 µg
EUR 250

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx112119-100l 100 µl
EUR 612.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx112119
  • Ask for price
  • Ask for price
  • 50 ul
  • 150 ul

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